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Issue 86, 2014
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Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates

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Abstract

Inspired by the isothermal enzymatic process of rolling circle amplification (RCA) of DNA strands, we have developed a system to achieve more than a 200-fold increase in the synthesis of DNA nanostructures using a single-stranded circular DNA template. The amplified DNA nanostructures have shown efficient delivery of folic acid (FA) conjugated siRNAs into KB cells with a dose dependent gene silencing.

Graphical abstract: Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates

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Supplementary files

Article information


Submitted
20 May 2014
Accepted
16 Jun 2014
First published
17 Jun 2014

Chem. Commun., 2014,50, 13049-13051
Article type
Communication
Author version available

Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates

C. A. Hong, B. Jang, E. H. Jeong, H. Jeong and H. Lee, Chem. Commun., 2014, 50, 13049
DOI: 10.1039/C4CC03834G

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