Issue 64, 2014
From the journal:

Chemical Communications

C5-Amino acid functionalized LNA: positively poised for antisense applications†

Dale C. Guenther,a   Pawan Kumar,a   Brooke A. Andersona  and  Patrick J. Hrdlicka*a  

* Corresponding authors

a Department of Chemistry, University of Idaho, 875 Perimeter Drive MS2343, Moscow, ID, USA
E-mail: hrdlicka@uidaho.edu

Abstract

Incorporation of positively charged C5-amino acid functionalized LNA uridines into oligodeoxyribonucleotides (ONs) results in extraordinary RNA affinity, binding specificity and stability towards 3′-exonucleases.

Graphical abstract: C5-Amino acid functionalized LNA: positively poised for antisense applications

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Article information

DOI
https://doi.org/10.1039/C4CC03623A
Article type
Communication
Submitted
13 May 2014
Accepted
10 Jun 2014
First published
10 Jun 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 9007-9009

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C5-Amino acid functionalized LNA: positively poised for antisense applications

D. C. Guenther, P. Kumar, B. A. Anderson and P. J. Hrdlicka, Chem. Commun., 2014, 50, 9007 DOI: 10.1039/C4CC03623A

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