Electron deficient azides are challenging substrates in CuAAC reactions. Particularly, when N-carbonyl azides are applied the formation of N-carbonyl triazoles has not yet been observed. We report herein the first example of this class of reaction, with a copper-based system that efficiently enables the synthesis of N-carbamoyl 1,2,3-triazoles by [3+2] cycloaddition of N-carbamoyl azides and alkynes.
E. Haldón, E. Álvarez, M. Carmen Nicasio and P. J. Pérez, Chem. Commun., 2014, 50, 8978 DOI: 10.1039/C4CC03614J
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