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Issue 70, 2014
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Bio-specific and bio-orthogonal chemistries to switch-off the quencher of a FRET-based fluorescent probe: application to living-cell biothiol imaging

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Abstract

We report the first molecular system that is responsive to both a bio-specific and a bio-orthogonal stimulus. This dual activation process was applied to the design of a biothiol-specific FRET-based fluorescent probe that could be turned-on via an original concept of quencher bleaching.

Graphical abstract: Bio-specific and bio-orthogonal chemistries to switch-off the quencher of a FRET-based fluorescent probe: application to living-cell biothiol imaging

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Supplementary files

Article information


Submitted
11 May 2014
Accepted
03 Jul 2014
First published
18 Jul 2014

Chem. Commun., 2014,50, 10049-10051
Article type
Communication
Author version available

Bio-specific and bio-orthogonal chemistries to switch-off the quencher of a FRET-based fluorescent probe: application to living-cell biothiol imaging

C. Egloff, S. A. Jacques, M. Nothisen, D. Weltin, C. Calligaro, M. Mosser, J.-S. Remy and A. Wagner, Chem. Commun., 2014, 50, 10049
DOI: 10.1039/C4CC03548H

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