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Issue 71, 2014
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Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates

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Abstract

We describe herein the synthesis and immunological evaluation of self-adjuvanting mucin 1 (MUC1)–macrophage activating lipopeptide 2 (MALP2) (glyco)peptide vaccine candidates. Vaccine constructs were shown to induce high titres of class-switched IgG antibodies in C57BL/6 mice after four immunisations despite the lack of a helper T cell epitope.

Graphical abstract: Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates

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Publication details

The article was received on 09 May 2014, accepted on 18 Jul 2014 and first published on 18 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC03510K
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Chem. Commun., 2014,50, 10273-10276

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    Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates

    D. M. McDonald, B. L. Wilkinson, L. Corcilius, M. Thaysen-Andersen, S. N. Byrne and R. J. Payne, Chem. Commun., 2014, 50, 10273
    DOI: 10.1039/C4CC03510K

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