Issue 71, 2014
From the journal:

Chemical Communications

Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates†

David M. McDonald,ab   Brendan L. Wilkinson,a   Leo Corcilius,a   Morten Thaysen-Andersen,c   Scott N. Byrneb  and  Richard J. Payne*a  

* Corresponding authors

a School of Chemistry, The University of Sydney, NSW 2006, Australia
E-mail: richard.payne@sydney.edu.au

b Discipline of Infectious Diseases and Immunology, The University of Sydney, NSW 2006, Australia

c Department of Chemistry and Biomolecular Sciences, Macquarie University, NSW 2109, Australia

Abstract

We describe herein the synthesis and immunological evaluation of self-adjuvanting mucin 1 (MUC1)–macrophage activating lipopeptide 2 (MALP2) (glyco)peptide vaccine candidates. Vaccine constructs were shown to induce high titres of class-switched IgG antibodies in C57BL/6 mice after four immunisations despite the lack of a helper T cell epitope.

Graphical abstract: Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates

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Article information

DOI
https://doi.org/10.1039/C4CC03510K
Article type
Communication
Submitted
09 May 2014
Accepted
18 Jul 2014
First published
18 Jul 2014

Chem. Commun., 2014,50, 10273-10276

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Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates

D. M. McDonald, B. L. Wilkinson, L. Corcilius, M. Thaysen-Andersen, S. N. Byrne and R. J. Payne, Chem. Commun., 2014, 50, 10273 DOI: 10.1039/C4CC03510K

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