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Issue 60, 2014
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A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes

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Abstract

We present the synthesis and characterisation of naphthalimide-flavin redox sensor 1 (NpFR1), a novel flavin molecule that is almost non-fluorescent in reduced form, but oxidation gives rise to a 125-fold increase in fluorescence. Confocal microscopy experiments confirm that NpFR1 is sensitive to redox changes within living cells.

Graphical abstract: A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes

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Supplementary files

Article information


Submitted
08 May 2014
Accepted
05 Jun 2014
First published
05 Jun 2014

This article is Open Access

Chem. Commun., 2014,50, 8181-8184
Article type
Communication

A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes

J. Yeow, A. Kaur, M. D. Anscomb and E. J. New, Chem. Commun., 2014, 50, 8181
DOI: 10.1039/C4CC03464C

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