Guobin Ma, Wen Wan, Qingyang Hu, Haizhen Jiang, Jing Wang, Shizheng Zhu and Jian Hao
Chem. Commun., 2014,50, 7527-7530
DOI:
10.1039/C4CC03321C,
Communication
A copper-mediated gem-difluoromethylenation of aryl, heteroaryl and vinyl boronic acids with bromodifluoromethylated oxazole or thiazole derivatives has been developed. This novel reaction showed an excellent functional group tolerance and wide substrate scope, providing facile access to practical application in drug discovery and development.