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Issue 60, 2014
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Covalent, sequence-specific attachment of long DNA molecules to a surface using DNA-templated click chemistry

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Abstract

We present a novel method that covalently and sequence-specifically attaches long DNA molecules to a surface that is compatible with high-resolution atomic force microscopy (AFM) imaging. Surfaces prepared with this approach are ideally suited for performing biophysical experiments on single DNA molecules.

Graphical abstract: Covalent, sequence-specific attachment of long DNA molecules to a surface using DNA-templated click chemistry

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Article information


Submitted
19 Apr 2014
Accepted
04 Jun 2014
First published
06 Jun 2014

This article is Open Access

Chem. Commun., 2014,50, 8131-8133
Article type
Communication
Author version available

Covalent, sequence-specific attachment of long DNA molecules to a surface using DNA-templated click chemistry

G. R. Abel, B. H. Cao, J. E. Hein and T. Ye, Chem. Commun., 2014, 50, 8131 DOI: 10.1039/C4CC02900C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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