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Issue 56, 2014
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Visible-light-induced direct C(sp3)–H difluromethylation of tetrahydroisoquinolines with the in situ generated difluoroenolates

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Abstract

An effective approach to C1-difluoromethylated tetrahydroisoquinoline derivatives has been developed through C–H functionalization of tertiary amines by visible-light photoredox catalysis. This method uses stable, easily obtained α,α-difluorinated gem-diol as the CF2 source. The corresponding products were obtained in moderate to high yields at ambient temperature.

Graphical abstract: Visible-light-induced direct C(sp3)–H difluromethylation of tetrahydroisoquinolines with the in situ generated difluoroenolates

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Supplementary files

Article information


Submitted
15 Apr 2014
Accepted
21 May 2014
First published
22 May 2014

Chem. Commun., 2014,50, 7521-7523
Article type
Communication
Author version available

Visible-light-induced direct C(sp3)–H difluromethylation of tetrahydroisoquinolines with the in situ generated difluoroenolates

W. Li, X. Zhu, H. Mao, Z. Tang, Y. Cheng and C. Zhu, Chem. Commun., 2014, 50, 7521
DOI: 10.1039/C4CC02768J

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