Issue 58, 2014
From the journal:

Chemical Communications

Chemoselective reduction of α-keto amides using nickel catalysts†

N. Chary Mamillapallia  and  Govidasamy Sekar*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Madras, Chennai, India
E-mail: gsekar@iitm.ac.in
Fax: +91 44 2257 4202
Tel: +91 44 2257 4229

Abstract

Ni-catalysts are used for the first time to synthesize highly important α-hydroxy amides and β-amino alcohols from α-keto amides by chemoselective and complete reduction using hydrosilanes. Chemoselective complete reduction of α-keto amides in the presence of a simple amide group is a key benefit of these Ni-catalysts.

Graphical abstract: Chemoselective reduction of α-keto amides using nickel catalysts

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Article information

DOI
https://doi.org/10.1039/C4CC02744B
Article type
Communication
Submitted
14 Apr 2014
Accepted
22 May 2014
First published
29 May 2014

Chem. Commun., 2014,50, 7881-7884

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Chemoselective reduction of α-keto amides using nickel catalysts

N. C. Mamillapalli and G. Sekar, Chem. Commun., 2014, 50, 7881 DOI: 10.1039/C4CC02744B

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