Issue 56, 2014
From the journal:

Chemical Communications

Glycoligand-targeted core–shell nanospheres with tunable drug release profiles from calixarene–cyclodextrin heterodimers†

Laura Gallego-Yerga,a   Michela Lomazzi,b   Francesco Sansone,*b   Carmen Ortiz Mellet,*a   Alessandro Casnatib  and  José M. García Fernández*c  

* Corresponding authors

a Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, E-41012 Sevilla, Spain
E-mail: mellet@us.es
Fax: +34 9546 24960
Tel: +34 9545 59806

b Dipartimento di Chimica, Università degli Studi di Parma, I-43124 Parma, Italy
E-mail: francesco.sansone@unipr.it
Fax: +39 0521 905472
Tel: +39 0521 905458

c Instituto de Investigaciones Químicas (IIQ), CSIC – Universidad de Sevilla, E-41092 Sevilla, Spain
E-mail: jogarcia@iiq.csic.es
Fax: +34 9544 60165
Tel: +34 9544 89553

Abstract

Stable core–shell nanospheres self-assemble in water from heterodimers combining a hydrophobic calix[4]arene moiety and a hydrophilic β-cyclodextrin head; their potential to encapsulate and provide sustained release of the anticancer drug docetaxel and undergo surface post-modification with glycoligands targeting the macrophage mannose receptor is discussed.

Graphical abstract: Glycoligand-targeted core–shell nanospheres with tunable drug release profiles from calixarene–cyclodextrin heterodimers

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Article information

DOI
https://doi.org/10.1039/C4CC02703E
Article type
Communication
Submitted
11 Apr 2014
Accepted
15 May 2014
First published
19 May 2014

Chem. Commun., 2014,50, 7440-7443

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Glycoligand-targeted core–shell nanospheres with tunable drug release profiles from calixarene–cyclodextrin heterodimers

L. Gallego-Yerga, M. Lomazzi, F. Sansone, C. Ortiz Mellet, A. Casnati and J. M. García Fernández, Chem. Commun., 2014, 50, 7440 DOI: 10.1039/C4CC02703E

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