Issue 52, 2014
From the journal:

Chemical Communications

Label-free, optical sensing of the supramolecular assembly into fibrils of a ditryptophan–DNA hybrid†

Nidhi Gour,‡a   Jancy Nixon Abraham,‡a   Mohamed Chami,b   Axel Castillo,a   Sandeep Vermac  and  Corinne Vebert-Nardin*a  

* Corresponding authors

a University of Geneva, Faculty of Sciences, Department of Inorganic and Analytical Chemistry, 1211 Geneva 4, Switzerland
E-mail: corinne.vebert@unige.ch
Fax: +41 22 379 60 69
Tel: +41 22 379 64 22

b Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University Basel, Mattenstrasse 26, CH-4058 Basel, Switzerland
E-mail: mohamed.chami@unibas.ch
Fax: +41-61-387 39 86
Tel: +41-61-387 32 24

c Department of Chemistry, Centre for Environmental Sciences and Engineering, DST Thematic Unit of Excellence on Soft Nanofabrication, Indian Institute of Technology Kanpur, India
E-mail: sverma@iitk.ac.in
Tel: +91-512-259-7643

Abstract

The grafting of a short nucleic acid strand to ditryptophan dipeptide (WW) results in a peptide–DNA hybrid, which assembles into fibrils under controlled aggregation conditions as evidenced by label free optical sensing owing to the intrinsic fluorescence of the dipeptide.

Graphical abstract: Label-free, optical sensing of the supramolecular assembly into fibrils of a ditryptophan–DNA hybrid

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Article information

DOI
https://doi.org/10.1039/C4CC02631D
Article type
Communication
Submitted
09 Apr 2014
Accepted
13 May 2014
First published
13 May 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 6863-6865

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Label-free, optical sensing of the supramolecular assembly into fibrils of a ditryptophan–DNA hybrid

N. Gour, J. N. Abraham, M. Chami, A. Castillo, S. Verma and C. Vebert-Nardin, Chem. Commun., 2014, 50, 6863 DOI: 10.1039/C4CC02631D

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