An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles

Manjusha V. Karkhelikar; Rajeev R. Jha; B. Sridhar; Pravin R. Likhar; Akhilesh K. Verma

doi:10.1039/C4CC02466D

An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles†

Manjusha V. Karkhelikar,^a Rajeev R. Jha,^b B. Sridhar,^c Pravin R. Likhar*^a and Akhilesh K. Verma*^b

* Corresponding authors

^a Organometallic Group, Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Hyderabad-500007, India
E-mail: plikhar@iict.res.in

^b Department of Chemistry, University of Delhi, Delhi-110007, India
E-mail: averma@acbr.du.ac.in

^c X-Ray Crystallography Center, Indian Institute of Chemical Technology, Hyderabad-500007, India

Abstract

An efficient approach for the synthesis of pyrrolo[3,2-c]quinolines (the core nucleus of the natural product martinellic acid) from protected 2-alkynylanilines via the regioselective formation of pyrroles followed by Heck and intramolecular Michael addition has been described.

Supplementary files

Publication details

The article was received on 03 Apr 2014, accepted on 07 May 2014 and first published on 20 Jun 2014

Article type: Communication

DOI: 10.1039/C4CC02466D

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available: Download author version (PDF)

Citation: Chem. Commun., 2014,50, 8526-8528

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An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles

M. V. Karkhelikar, R. R. Jha, B. Sridhar, P. R. Likhar and A. K. Verma, Chem. Commun., 2014, 50, 8526
DOI: 10.1039/C4CC02466D
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Chemical Communications

An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles†

Abstract

Supplementary files

Publication details

An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles

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