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Issue 62, 2014
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An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles

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Abstract

An efficient approach for the synthesis of pyrrolo[3,2-c]quinolines (the core nucleus of the natural product martinellic acid) from protected 2-alkynylanilines via the regioselective formation of pyrroles followed by Heck and intramolecular Michael addition has been described.

Graphical abstract: An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles

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Article information


Submitted
03 Apr 2014
Accepted
07 May 2014
First published
20 Jun 2014

Chem. Commun., 2014,50, 8526-8528
Article type
Communication
Author version available

An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles

M. V. Karkhelikar, R. R. Jha, B. Sridhar, P. R. Likhar and A. K. Verma, Chem. Commun., 2014, 50, 8526
DOI: 10.1039/C4CC02466D

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