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Issue 62, 2014
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An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles

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Abstract

An efficient approach for the synthesis of pyrrolo[3,2-c]quinolines (the core nucleus of the natural product martinellic acid) from protected 2-alkynylanilines via the regioselective formation of pyrroles followed by Heck and intramolecular Michael addition has been described.

Graphical abstract: An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles

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The article was received on 03 Apr 2014, accepted on 07 May 2014 and first published on 20 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC02466D
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Chem. Commun., 2014,50, 8526-8528

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    An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles

    M. V. Karkhelikar, R. R. Jha, B. Sridhar, P. R. Likhar and A. K. Verma, Chem. Commun., 2014, 50, 8526
    DOI: 10.1039/C4CC02466D

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