Issue 63, 2014
From the journal:

Chemical Communications

A lock-and-key mechanism for the controllable fabrication of DNA origami structures†

Arivazhagan Rajendran,‡a   Masayuki Endo,*bc   Kumi Hidaka,a   Naohiko Shimada,d   Atsushi Maruyamad  and  Hiroshi Sugiyama*abc  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan
E-mail: hs@kuchem.kyoto-u.ac.jp

b Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida-ushinomiyacho, Sakyo-ku, Kyoto 606-8501, Japan
E-mail: endo@kuchem.kyoto-u.ac.jp

c CREST, JST, Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan

d Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259, Midori-ku, Yokohama 226-8501, Japan

Abstract

Controllable fabrication of DNA origami structures was achieved using cationic comb-type copolymers (CCCs) as locks and polyvinyl sulphonic acid (PVS) as a key. A CCC binds to the phosphate backbone of either M13mp18/staples alone or both together and restricts origami folding, while PVS unlocks the CCC, restoring the formation of origami structures.

Graphical abstract: A lock-and-key mechanism for the controllable fabrication of DNA origami structures

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Article information

DOI
https://doi.org/10.1039/C4CC02244K
Article type
Communication
Submitted
26 Mar 2014
Accepted
05 Jun 2014
First published
05 Jun 2014

Chem. Commun., 2014,50, 8743-8746

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A lock-and-key mechanism for the controllable fabrication of DNA origami structures

A. Rajendran, M. Endo, K. Hidaka, N. Shimada, A. Maruyama and H. Sugiyama, Chem. Commun., 2014, 50, 8743 DOI: 10.1039/C4CC02244K

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