Issue 43, 2014
From the journal:

Chemical Communications

Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe†

Yeon Ok Lee,‡a   Jung-Won Shin,‡b   Chunsik Yi,b   Yun Hak Lee,a   Nak-Won Sohn,*b   Chulhun Kang*b  and  Jong Seung Kim*a  

* Corresponding authors

a Department of Chemistry, Korea University, Seoul 136-701, Korea
E-mail: jongskim@korea.ac.kr

b School of East-West Medical Science, Kyung Hee University, Yongin 446-701, Korea
E-mail: sohnnw@khu.ac.kr, kangch@khu.ac.kr

Abstract

We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Aβ aggregates and Aβ fibrils. Upon injection into Aβ42-challenged mouse brains, probe 1 shows increased fluorescence intensity, indicating its facile binding to extracellular Aβ fibrils in brain tissues.

Graphical abstract: Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4CC02011A
Article type
Communication
Submitted
18 Mar 2014
Accepted
05 Apr 2014
First published
07 Apr 2014

Chem. Commun., 2014,50, 5741-5744

Permissions

Request permissions

Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe

Y. O. Lee, J. Shin, C. Yi, Y. H. Lee, N. Sohn, C. Kang and J. S. Kim, Chem. Commun., 2014, 50, 5741 DOI: 10.1039/C4CC02011A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements