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Issue 41, 2014
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Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens

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Abstract

The biosynthesis of tropodithietic acid was investigated using a combinatorial approach of feeding experiments, gene knockouts and bioinformatic analyses. The mechanism of sulfur introduction is distinct from known mechanisms in holomycin, thiomarinol A and gliotoxin biosynthesis.

Graphical abstract: Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens

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Article information


Submitted
14 Mar 2014
Accepted
03 Apr 2014
First published
10 Apr 2014

Chem. Commun., 2014,50, 5487-5489
Article type
Communication

Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens

N. L. Brock, A. Nikolay and J. S. Dickschat, Chem. Commun., 2014, 50, 5487
DOI: 10.1039/C4CC01924E

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