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Issue 62, 2014
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From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins

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Abstract

The synthesis of one of the most potent dual inhibitors of the anti-apoptotic proteins Bcl-xL and Mcl-1 is reported. This analogue of a natural sesquiterpenoid dimer meiogynin A was elaborated by a convergent asymmetric synthesis with 36% yield in ten steps.

Graphical abstract: From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins

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Supplementary files

Article information


Submitted
11 Mar 2014
Accepted
08 Jun 2014
First published
11 Jun 2014

Chem. Commun., 2014,50, 8593-8596
Article type
Communication

From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins

S. Desrat, C. Remeur, C. Gény, G. Rivière, C. Colas, V. Dumontet, N. Birlirakis, B. I. Iorga and F. Roussi, Chem. Commun., 2014, 50, 8593
DOI: 10.1039/C4CC01830C

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