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Issue 38, 2014
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A concise [C+NC+CC] coupling-enabled synthesis of kaitocephalin

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Abstract

A 15-step synthesis of the iGluR antagonist kaitocephalin from aspartic acid is reported. The linchpin pyrrolidine ring of the target molecule is efficiently assembled with in a single operation via an asymmetric [C+NC+CC] reaction.

Graphical abstract: A concise [C+NC+CC] coupling-enabled synthesis of kaitocephalin

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Publication details

The article was received on 06 Mar 2014, accepted on 27 Mar 2014 and first published on 02 Apr 2014


Article type: Communication
DOI: 10.1039/C4CC01692K
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Chem. Commun., 2014,50, 4908-4910

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    A concise [C+NC+CC] coupling-enabled synthesis of kaitocephalin

    P. Garner, L. Weerasinghe, I. Van Houten and J. Hu, Chem. Commun., 2014, 50, 4908
    DOI: 10.1039/C4CC01692K

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