Issue 36, 2014

Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors

Abstract

We incorporated short thiolated oligonucleotides as passivating diluents in the fabrication of electrochemical peptide-based (E-PB) sensors, with the goal of creating a negatively charged layer capable of resisting non-specific adsorption of matrix contaminants. The E-PB HIV sensors fabricated using these diluents were found to be more specific and selective, while retaining attributes similar to the sensor fabricated without these diluents. Overall, these results highlight the advantages of using oligonucleotides as anti-fouling diluents in self-assembled monolayer-based sensors.

Graphical abstract: Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors

Supplementary files

Article information

Article type
Communication
Submitted
19 Feb 2014
Accepted
13 Mar 2014
First published
17 Mar 2014
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2014,50, 4690-4692

Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors

A. McQuistan, A. J. Zaitouna, E. Echeverria and R. Y. Lai, Chem. Commun., 2014, 50, 4690 DOI: 10.1039/C4CC01290A

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