Jump to main content
Jump to site search

Issue 36, 2014
Previous Article Next Article

Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors

Author affiliations

Abstract

We incorporated short thiolated oligonucleotides as passivating diluents in the fabrication of electrochemical peptide-based (E-PB) sensors, with the goal of creating a negatively charged layer capable of resisting non-specific adsorption of matrix contaminants. The E-PB HIV sensors fabricated using these diluents were found to be more specific and selective, while retaining attributes similar to the sensor fabricated without these diluents. Overall, these results highlight the advantages of using oligonucleotides as anti-fouling diluents in self-assembled monolayer-based sensors.

Graphical abstract: Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors

Back to tab navigation

Supplementary files

Article information


Submitted
19 Feb 2014
Accepted
13 Mar 2014
First published
17 Mar 2014

This article is Open Access

Chem. Commun., 2014,50, 4690-4692
Article type
Communication

Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors

A. McQuistan, A. J. Zaitouna, E. Echeverria and R. Y. Lai, Chem. Commun., 2014, 50, 4690
DOI: 10.1039/C4CC01290A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements