Issue 30, 2014
From the journal:

Chemical Communications

Construction of a crown ether-like supramolecular library by conjugation of genetically-encoded peptide linkers displayed on bacteriophage T7†

Keisuke Fukunaga,a   Takaaki Hatanaka,‡a   Yuji Ito,‡a   Michiko Minami§a  and  Masumi Taki*a  

* Corresponding authors

a Department of Engineering Science, Bioscience and Technology Program, The Graduate School of Informatics and Engineering, The University of Electro-Communications (UEC), 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan
E-mail: taki@pc.uec.ac.jp
Tel: +81-42-443-5980

Abstract

By using the 10BASEd-T, we have synthesized a crown ether-like macrocyclic library possessing randomized peptide linkers on bacteriophage T7. Among 1.5 × 109 diversities of the supramolecule candidates, we have obtained a specific binder for the N-terminal domain of Hsp90.

Graphical abstract: Construction of a crown ether-like supramolecular library by conjugation of genetically-encoded peptide linkers displayed on bacteriophage T7

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Article information

DOI
https://doi.org/10.1039/C4CC00811A
Article type
Communication
Submitted
30 Jan 2014
Accepted
22 Feb 2014
First published
24 Feb 2014

Chem. Commun., 2014,50, 3921-3923

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Construction of a crown ether-like supramolecular library by conjugation of genetically-encoded peptide linkers displayed on bacteriophage T7

K. Fukunaga, T. Hatanaka, Y. Ito, M. Minami and M. Taki, Chem. Commun., 2014, 50, 3921 DOI: 10.1039/C4CC00811A

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