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Issue 30, 2014
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Construction of a crown ether-like supramolecular library by conjugation of genetically-encoded peptide linkers displayed on bacteriophage T7

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Abstract

By using the 10BASEd-T, we have synthesized a crown ether-like macrocyclic library possessing randomized peptide linkers on bacteriophage T7. Among 1.5 × 109 diversities of the supramolecule candidates, we have obtained a specific binder for the N-terminal domain of Hsp90.

Graphical abstract: Construction of a crown ether-like supramolecular library by conjugation of genetically-encoded peptide linkers displayed on bacteriophage T7

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Publication details

The article was received on 30 Jan 2014, accepted on 22 Feb 2014 and first published on 24 Feb 2014


Article type: Communication
DOI: 10.1039/C4CC00811A
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Citation: Chem. Commun., 2014,50, 3921-3923

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    Construction of a crown ether-like supramolecular library by conjugation of genetically-encoded peptide linkers displayed on bacteriophage T7

    K. Fukunaga, T. Hatanaka, Y. Ito, M. Minami and M. Taki, Chem. Commun., 2014, 50, 3921
    DOI: 10.1039/C4CC00811A

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