Issue 26, 2014
From the journal:

Chemical Communications

Ratiometric fluorescence assay for γ-glutamyltranspeptidase detection based on a single fluorophore via analyte-induced variation of substitution†

Xianfeng Hou,a   Qingxiang Yu,a   Fang Zeng,*a   Changmin Yua  and  Shuizhu Wu*a  

* Corresponding authors

a College of Materials Science & Engineering, State Key Lab of Luminescent Materials & Devices, South China University of Technology, Guangzhou 510640, P. R. China
E-mail: mcfzeng@scut.edu.cn, shzhwu@scut.edu.cn
Fax: +86 20 22236363
Tel: +86 20 22236262

Abstract

The first ratiometric fluorescent probe for γ-glutamyltranspeptidase (GGT) was developed, which functions through GGT-induced variation of substitution and subsequent changes in photophysical properties. It can detect GGT in human serum, and be used to visualize the endogenous GGT in ovarian cancer cells.

Graphical abstract: Ratiometric fluorescence assay for γ-glutamyltranspeptidase detection based on a single fluorophore via analyte-induced variation of substitution

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Article information

DOI
https://doi.org/10.1039/C4CC00473F
Article type
Communication
Submitted
20 Jan 2014
Accepted
10 Feb 2014
First published
10 Feb 2014

Chem. Commun., 2014,50, 3417-3420

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Ratiometric fluorescence assay for γ-glutamyltranspeptidase detection based on a single fluorophore via analyte-induced variation of substitution

X. Hou, Q. Yu, F. Zeng, C. Yu and S. Wu, Chem. Commun., 2014, 50, 3417 DOI: 10.1039/C4CC00473F

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