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Issue 56, 2014
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The ligation of aspirin to cisplatin demonstrates significant synergistic effects on tumor cells

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Abstract

Asplatin, a fusion of aspirin and cisplatin, exhibits significant cytotoxicity in tumor cells and almost fully overcomes the drug resistance of cisplatin resistant cells. Asplatin is highly accumulated in cancer cells and is activated upon the reduction by ascorbic acid.

Graphical abstract: The ligation of aspirin to cisplatin demonstrates significant synergistic effects on tumor cells

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Supplementary files

Article information


Submitted
17 Jan 2014
Accepted
27 Feb 2014
First published
28 Feb 2014

Chem. Commun., 2014,50, 7427-7430
Article type
Communication
Author version available

The ligation of aspirin to cisplatin demonstrates significant synergistic effects on tumor cells

Q. Cheng, H. Shi, H. Wang, Y. Min, J. Wang and Y. Liu, Chem. Commun., 2014, 50, 7427
DOI: 10.1039/C4CC00419A

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