Issue 33, 2014
From the journal:

Chemical Communications

Proteome reactivity profiling for the discrimination of pathogenic bacteria†

Jun-Seok Lee,*ab   Young-Hwa Yoo,a   Jihye Kang,a   Won Seok Han,a   Jin Kak Leec  and  Chang No Yoon*a  

* Corresponding authors

a Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seoul, Korea
E-mail: junseoklee@kist.re.kr

b University of Science & Technology, 113 Gwahank-ro, Yuseong-gu, Daejeon 305-333, Korea

c Nanormics Inc., 10-57 Hawolgokdong, Seoul 136-865, Korea

Abstract

Diverse proteome reactivity profiles were obtained using small-molecule electrophiles. Based on the cross-reactivity profile, each protein generated a unique reactivity fingerprint. Here, we report the first proteome reactivity signature-based discrimination of 11 bacteria. Perfect differentiation of 11 bacteria can be achieved using 2 benzyl-halide probes.

Graphical abstract: Proteome reactivity profiling for the discrimination of pathogenic bacteria

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Article information

DOI
https://doi.org/10.1039/C4CC00320A
Article type
Communication
Submitted
15 Jan 2014
Accepted
06 Mar 2014
First published
07 Mar 2014

Chem. Commun., 2014,50, 4347-4350

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Proteome reactivity profiling for the discrimination of pathogenic bacteria

J. Lee, Y. Yoo, J. Kang, W. S. Han, J. K. Lee and C. N. Yoon, Chem. Commun., 2014, 50, 4347 DOI: 10.1039/C4CC00320A

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