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Issue 39, 2014

Polypeptide films via N-carboxyanhydride ring-opening polymerization (NCA-ROP): past, present and future

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Abstract

The formation of surface-grafted polypeptide films and interfaces via N-carboxyanhydride ring-opening polymerization (NCA-ROP) holds great potential for the facile preparation of next-generation multifunctional and responsive materials with excellent biocompatibility, biodegradability, tunable conformations and chemical functionalities. Therefore, the aim of this feature article is to provide a topical review of developments in the area of polypeptide films derived through NCA-ROP. It is evident that studies reported thus far have only started to unveil the full potential of peptide-based interfaces and materials, and with continued advancements it is anticipated that the strategic combination of NCA-ROP with modern synthetic chemistries will continue to yield versatile platforms for broader applications in the fields of polymer therapeutics, tissue engineering, (bio)nanocoatings, (bio)chemosensors, catalysis and separation technologies.

Graphical abstract: Polypeptide films via N-carboxyanhydride ring-opening polymerization (NCA-ROP): past, present and future

Article information


Submitted
13 Jan 2014
Accepted
17 Feb 2014
First published
17 Feb 2014

Chem. Commun., 2014,50, 4971-4988
Article type
Feature Article

Polypeptide films via N-carboxyanhydride ring-opening polymerization (NCA-ROP): past, present and future

S. H. Wibowo, A. Sulistio, E. H. H. Wong, A. Blencowe and G. G. Qiao, Chem. Commun., 2014, 50, 4971 DOI: 10.1039/C4CC00293H

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