Issue 22, 2014
From the journal:

Chemical Communications

Fluorous enzymatic synthesis of phosphatidylinositides†‡

Weigang Huang,a   Angela Proctor,b   Christopher E. Sims,b   Nancy L. Allbrittonbc  and  Qisheng Zhang*a  

* Corresponding authors

a Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
E-mail: qszhang@unc.edu
Fax: +1-919-966-0204
Tel: +1-919-966-9687

b Department of Chemistry, University of North Carolina at Chapel Hill, USA

c Department of Biomedical Engineering, University of North Carolina at Chapel Hill, USA

Abstract

A fluorous tagging strategy coupled with enzymatic synthesis is introduced to efficiently synthesize multiple phosphatidylinositides, which are then directly immobilized on a fluorous polytetrafluoroethylene (PTFE) membrane to probe protein–lipid interactions.

Graphical abstract: Fluorous enzymatic synthesis of phosphatidylinositides

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Article information

DOI
https://doi.org/10.1039/C4CC00022F
Article type
Communication
Submitted
02 Jan 2014
Accepted
28 Jan 2014
First published
29 Jan 2014

Chem. Commun., 2014,50, 2928-2931

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Fluorous enzymatic synthesis of phosphatidylinositides

W. Huang, A. Proctor, C. E. Sims, N. L. Allbritton and Q. Zhang, Chem. Commun., 2014, 50, 2928 DOI: 10.1039/C4CC00022F

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