Issue 29, 2014
From the journal:

Chemical Communications

Ni-catalyzed asymmetric reductive allylation of aldehydes with allylic carbonates†

Zhuozhen Tan,a   Xiaolong Wan,a   Zhenhua Zang,a   Qun Qian,*a   Wei Deng*a  and  Hegui Gong*a  

* Corresponding authors

a Department of Chemistry, Innovative Drug Research Center, and School of Materials Science and Engineering, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China
E-mail: Hegui_gong@shu.edu.cn

Abstract

This work features first asymmetric Ni-catalyzed reductive coupling of allylic carbonates with aldehydes, which may proceed via allyl-Ni intermediates although Zn was used as the terminal reductant. Moderate to excellent enantiomeric excess was obtained with excellent functional group tolerance.

Graphical abstract: Ni-catalyzed asymmetric reductive allylation of aldehydes with allylic carbonates

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Article information

DOI
https://doi.org/10.1039/C3CC49859J
Article type
Communication
Submitted
31 Dec 2013
Accepted
17 Feb 2014
First published
17 Feb 2014

Chem. Commun., 2014,50, 3827-3830

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Ni-catalyzed asymmetric reductive allylation of aldehydes with allylic carbonates

Z. Tan, X. Wan, Z. Zang, Q. Qian, W. Deng and H. Gong, Chem. Commun., 2014, 50, 3827 DOI: 10.1039/C3CC49859J

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