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Issue 24, 2014
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Efficient inhibition of human papillomavirus 16 L1 pentamer formation by a carboxylatopillarene and a p-sulfonatocalixarene

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Abstract

Pillarenes and calixarenes showed obvious inhibition of HPV16 L1 pentamer formation via their selective binding to Arg and Lys residues at the monomer interface, which was reversible after the release of cyclic arenes. Pillarenes are more effective than calixarenes in terms of the inhibition efficiency, attributing to the different kinetics and binding affinity.

Graphical abstract: Efficient inhibition of human papillomavirus 16 L1 pentamer formation by a carboxylatopillarene and a p-sulfonatocalixarene

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Article information


Submitted
26 Dec 2013
Accepted
29 Jan 2014
First published
29 Jan 2014

Chem. Commun., 2014,50, 3201-3203
Article type
Communication

Efficient inhibition of human papillomavirus 16 L1 pentamer formation by a carboxylatopillarene and a p-sulfonatocalixarene

D. Zheng, D. Fu, Y. Wu, Y. Sun, L. Tan, T. Zhou, S. Ma, X. Zha and Y. Yang, Chem. Commun., 2014, 50, 3201
DOI: 10.1039/C3CC49789E

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