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Issue 27, 2014
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Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation

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Abstract

DNA methylation has the potential to be a clinically important biomarker in cancer. This communication reports a real-time and label-free biosensing strategy for DNA methylation detection in the cancer cell line. This has been achieved by using surface plasmon resonance biosensing combined with the highly specific molecular inversion probe based amplification method, which requires only 50 ng of bisulfite treated genomic DNA.

Graphical abstract: Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation

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Supplementary files

Article information


Submitted
19 Dec 2013
Accepted
11 Feb 2014
First published
11 Feb 2014

Chem. Commun., 2014,50, 3585-3588
Article type
Communication
Author version available

Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation

L. G. Carrascosa, A. A. I. Sina, R. Palanisamy, B. Sepulveda, M. A. Otte, S. Rauf, M. J. A. Shiddiky and M. Trau, Chem. Commun., 2014, 50, 3585
DOI: 10.1039/C3CC49607D

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