Issue 18, 2014
From the journal:

Chemical Communications

Alkyne aminohalogenation enabled by DBU-activated N-haloimides: direct synthesis of halogenated enamines†

Mengru Li,a   Haiyan Yuan,a   Baozhong Zhao,a   Fushun Liang*ab  and  Jingping Zhang*a  

* Corresponding authors

a Department of Chemistry, Northeast Normal University, Changchun 130024, China
E-mail: liangfs112@nenu.edu.cn, zhangjp162@nenu.edu.cn
Fax: +86-431-85099759

b Key Laboratory for UV-Emitting Materials and Technology of Ministry of Education, Northeast Normal University, Changchun 130024, China

Abstract

Activated by DBU, N-haloimides can be used as both halogen and nitrogen sources to achieve the difunctionalization of terminal alkynes, giving rise to useful halogenated enamines with high efficiency and high regio- and stereoselectivities. The cascade reaction features simple manipulation, mild conditions, a broad substrate scope, readily available reagents, and atom-economy.

Graphical abstract: Alkyne aminohalogenation enabled by DBU-activated N-haloimides: direct synthesis of halogenated enamines

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Article information

DOI
https://doi.org/10.1039/C3CC49572H
Article type
Communication
Submitted
18 Dec 2013
Accepted
07 Jan 2014
First published
08 Jan 2014

Chem. Commun., 2014,50, 2360-2363

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Alkyne aminohalogenation enabled by DBU-activated N-haloimides: direct synthesis of halogenated enamines

M. Li, H. Yuan, B. Zhao, F. Liang and J. Zhang, Chem. Commun., 2014, 50, 2360 DOI: 10.1039/C3CC49572H

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