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Issue 20, 2014
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The genetic incorporation of thirteen novel non-canonical amino acids

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Abstract

Thirteen novel non-canonical amino acids were synthesized and tested for suppression of an amber codon using a mutant pyrrolysyl-tRNA synthetase–tRNAPylCUA pair. Suppression was observed with varied efficiencies. One non-canonical amino acid in particular contains an azide that can be applied for site-selective protein labeling.

Graphical abstract: The genetic incorporation of thirteen novel non-canonical amino acids

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Article information


Submitted
27 Nov 2013
Accepted
09 Jan 2014
First published
17 Jan 2014

Chem. Commun., 2014,50, 2673-2675
Article type
Communication
Author version available

The genetic incorporation of thirteen novel non-canonical amino acids

A. Tuley, Y. Wang, X. Fang, Y. Kurra, Y. H. Rezenom and W. R. Liu, Chem. Commun., 2014, 50, 2673
DOI: 10.1039/C3CC49068H

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