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Issue 11, 2014
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Construction of DNA–polymer hybrids using intercalation interactions

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Abstract

Reversible addition–fragmentation chain transfer (RAFT) polymerisation was used to produce a range of polymers terminated with an acridine group, which intercalates efficiently into dsDNA; the structure of the polymer determines the nature and strength of the interaction. Using a short 63 base pair dsDNA, discrete and well-defined DNA–polymer hybrid nanoparticles were formed, which were characterised by dynamic light scattering, small-angle X-ray scattering and atomic force microscopy.

Graphical abstract: Construction of DNA–polymer hybrids using intercalation interactions

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Article information


Submitted
15 Nov 2013
Accepted
09 Dec 2013
First published
17 Dec 2013

Chem. Commun., 2014,50, 1338-1340
Article type
Communication

Construction of DNA–polymer hybrids using intercalation interactions

T. R. Wilks, A. Pitto-Barry, N. Kirby, E. Stulz and R. K. O'Reilly, Chem. Commun., 2014, 50, 1338
DOI: 10.1039/C3CC48726A

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