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Issue 10, 2014
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Enhanced cellular uptake of amphiphilic gold nanoparticles with ester functionality

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Abstract

Gold nanoparticles (AuNPs) coated with ester-headed or ether-headed PEG ligands were synthesized. Ester-headed AuNPs, but not ether-headed, were transferred from the organic phase (CH2Cl2) to the alkali aqueous phase, indicating that the hydrolysis of the ester moiety triggered the phase transfer of the AuNPs. We found that AuNPs with ester-headed ligands (ester-AuNPs) were internalized into HeLa cells at a greater level than were ether-headed AuNPs.

Graphical abstract: Enhanced cellular uptake of amphiphilic gold nanoparticles with ester functionality

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Submitted
08 Nov 2013
Accepted
26 Nov 2013
First published
26 Nov 2013

Chem. Commun., 2014,50, 1265-1267
Article type
Communication
Author version available

Enhanced cellular uptake of amphiphilic gold nanoparticles with ester functionality

K. Kobayashi, K. Niikura, C. Takeuchi, S. Sekiguchi, T. Ninomiya, K. Hagiwara, H. Mitomo, Y. Ito, Y. Osada and K. Ijiro, Chem. Commun., 2014, 50, 1265
DOI: 10.1039/C3CC48532C

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