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Issue 32, 2014
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Circular permutation of chicken interleukin-1 beta enhances its thermostability

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Abstract

Interleukin-1β is a cytokine critically involved in immune and inflammatory responses. To extend its use as a component of avian vaccines, a circularly permuted chicken interleukin-1β was synthesized that maintains its activity after pre-incubation at high temperatures, unlike wild-type chicken interleukin-1β, which is irreversibly inactivated at high temperatures.

Graphical abstract: Circular permutation of chicken interleukin-1 beta enhances its thermostability

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Publication details

The article was received on 30 Oct 2013, accepted on 28 Feb 2014 and first published on 03 Mar 2014


Article type: Communication
DOI: 10.1039/C3CC48313D
Citation: Chem. Commun., 2014,50, 4248-4250

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    Circular permutation of chicken interleukin-1 beta enhances its thermostability

    W. Chen, T. Chen, C. Cheng, W. Huang, X. Wang and H. Yin, Chem. Commun., 2014, 50, 4248
    DOI: 10.1039/C3CC48313D

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