Boron trihalide-promoted ring-opening reactions of gem-difluorocyclopropyl ketones to give the corresponding β-trifluoromethyl ketones and β-halodifluoromethyl ketones were described. It was found that boron trihalides act as both Lewis acids and nucleophiles and the proximal bond prefers to cleave in this transformation.
T. Yang, Q. Li, J. Lin and J. Xiao, Chem. Commun., 2014, 50, 1077 DOI: 10.1039/C3CC47879C
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