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Issue 23, 2014
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Single-point mutation detection in RNA extracts using gold nanoparticles modified with hydrophobic molecular beacon-like structures

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Abstract

Gold nanoparticles functionalized with oligonucleotides that bear a cholesterol group are used as gene sensors. The hydrophobic molecule is buried inside the nanostructure but when the complementary RNA sequence is present the structure unfolds exposing the cholesterol group to the water molecules. This rearrangement leads to the aggregation of the nanostructures.

Graphical abstract: Single-point mutation detection in RNA extracts using gold nanoparticles modified with hydrophobic molecular beacon-like structures

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Supplementary files

Article information


Submitted
13 Oct 2013
Accepted
15 Jan 2014
First published
05 Feb 2014

Chem. Commun., 2014,50, 3018-3020
Article type
Communication
Author version available

Single-point mutation detection in RNA extracts using gold nanoparticles modified with hydrophobic molecular beacon-like structures

A. Latorre, C. Posch, Y. Garcimartín, S. Ortiz-Urda and Á. Somoza, Chem. Commun., 2014, 50, 3018
DOI: 10.1039/C3CC47862A

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