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Issue 23, 2014
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Single-point mutation detection in RNA extracts using gold nanoparticles modified with hydrophobic molecular beacon-like structures

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Abstract

Gold nanoparticles functionalized with oligonucleotides that bear a cholesterol group are used as gene sensors. The hydrophobic molecule is buried inside the nanostructure but when the complementary RNA sequence is present the structure unfolds exposing the cholesterol group to the water molecules. This rearrangement leads to the aggregation of the nanostructures.

Graphical abstract: Single-point mutation detection in RNA extracts using gold nanoparticles modified with hydrophobic molecular beacon-like structures

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Publication details

The article was received on 13 Oct 2013, accepted on 15 Jan 2014 and first published on 05 Feb 2014


Article type: Communication
DOI: 10.1039/C3CC47862A
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Citation: Chem. Commun., 2014,50, 3018-3020
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    Single-point mutation detection in RNA extracts using gold nanoparticles modified with hydrophobic molecular beacon-like structures

    A. Latorre, C. Posch, Y. Garcimartín, S. Ortiz-Urda and Á. Somoza, Chem. Commun., 2014, 50, 3018
    DOI: 10.1039/C3CC47862A

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