Quanjun Wang, Xueying Liu, Xian Liu, Bin Li, Huifang Nie, Shengyong Zhang and Weiping Chen
Chem. Commun., 2014,50, 978-980
DOI:
10.1039/C3CC47727D,
Communication
Highly enantioselective hydrogenation of a variety of 2-substituted-2-alkenols has been achieved using a ChenPhos–Rh complex as catalyst, giving ≥99% ee for most substrates. Optically active antifungal agent amorolfine was first synthesised using hydrogenation as the key step.
