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Issue 8, 2014
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Highly enantioselective hydrogenation of 2-substituted-2-alkenols catalysed by a ChenPhos–Rh complex

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Abstract

Highly enantioselective hydrogenation of a variety of 2-substituted-2-alkenols has been achieved using a ChenPhos–Rh complex as catalyst, giving ≥99% ee for most substrates. Optically active antifungal agent amorolfine was first synthesised using hydrogenation as the key step.

Graphical abstract: Highly enantioselective hydrogenation of 2-substituted-2-alkenols catalysed by a ChenPhos–Rh complex

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Submitted
08 Oct 2013
Accepted
13 Nov 2013
First published
13 Nov 2013

Chem. Commun., 2014,50, 978-980
Article type
Communication

Highly enantioselective hydrogenation of 2-substituted-2-alkenols catalysed by a ChenPhos–Rh complex

Q. Wang, X. Liu, X. Liu, B. Li, H. Nie, S. Zhang and W. Chen, Chem. Commun., 2014, 50, 978
DOI: 10.1039/C3CC47727D

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