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Issue 18, 2014
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The ββα fold of zinc finger proteins as a “natural” protecting group. Chemoselective synthesis of a DNA-binding zinc finger derivative

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Abstract

We report the selective modification of cysteine residues engineered in peptides that have two additional cysteine residues as part of a Cys2His2 zinc finger motif. The chemoselective modification is achieved, thanks to the protecting effect exerted by the zinc cation upon coordination with the native cysteines and histidines of the zinc-finger fold. The strategy allows a straightforward synthesis of DNA binding zinc finger constructs.

Graphical abstract: The ββα fold of zinc finger proteins as a “natural” protecting group. Chemoselective synthesis of a DNA-binding zinc finger derivative

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Article information


Submitted
03 Oct 2013
Accepted
19 Dec 2013
First published
20 Dec 2013

Chem. Commun., 2014,50, 2258-2260
Article type
Communication

The ββα fold of zinc finger proteins as a “natural” protecting group. Chemoselective synthesis of a DNA-binding zinc finger derivative

J. Rodríguez, J. Mosquera, O. Vázquez, M. E. Vázquez and J. L. Mascareñas, Chem. Commun., 2014, 50, 2258
DOI: 10.1039/C3CC47599A

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