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The discovery that plant smoke contains germination stimuli has led to the identification of a new class of signaling molecules named karrikins. Here we report a potential second role for these molecules: in various bacterial species – A. tumefaciens, P. aeruginosa and V. harveyi – they modulate bacterial quorum-sensing (QS), with very different outcomes.

Graphical abstract: Karrikins from plant smoke modulate bacterial quorum sensing

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