Room-temperature Pd-catalyzed C–H chlorination by weak coordination: one-pot synthesis of 2-chlorophenols with excellent regioselectivity

Abstract

A room-temperature Pd(II)-catalyzed regioselective chlorination reaction has been developed for a facile one-pot synthesis of a broad range of 2-chlorophenols. The reaction demonstrates an excellent regioselectivity and reactivity for C–H chlorination. This reaction represents one of the rare examples of mild C–H functionalization at ambient temperature.