Issue 5, 2014
From the journal:

Chemical Communications

Synthesis of a photocontrollable hydrogen sulfide donor using ketoprofenate photocages†

Naoki Fukushima,a   Naoya Ieda,a   Kiyoshi Sasakura,b   Tetsuo Nagano,b   Kenjiro Hanaoka,b   Takayoshi Suzuki,c   Naoki Miyataa  and  Hidehiko Nakagawa*ad  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan
E-mail: deco@phar.nagoya-cu.ac.jp
Fax: +81 052 836 3407
Tel: +81 052 836 3407

b Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

c Graduate School of Medical Science Kyoto Prefectural University of Medicine, 13 Nishitakatsukasa-cho Taishogun Kita-ku, Kyoto 603-8334, Japan

d PRESTO, Japan Science and Technology Agency (JST), 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan

Abstract

We report the design, synthesis and application of a directly photocontrollable hydrogen sulfide (H2S) donor, which releases H2S proportionally to the intensity and duration of photoirradiation. Photocontrolled H2S release from this donor was also demonstrated in bovine serum. This H2S donor should be suitable for use in various biological systems.

Graphical abstract: Synthesis of a photocontrollable hydrogen sulfide donor using ketoprofenate photocages

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Article information

DOI
https://doi.org/10.1039/C3CC47421F
Article type
Communication
Submitted
28 Sep 2013
Accepted
05 Nov 2013
First published
05 Nov 2013

Chem. Commun., 2014,50, 587-589

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Synthesis of a photocontrollable hydrogen sulfide donor using ketoprofenate photocages

N. Fukushima, N. Ieda, K. Sasakura, T. Nagano, K. Hanaoka, T. Suzuki, N. Miyata and H. Nakagawa, Chem. Commun., 2014, 50, 587 DOI: 10.1039/C3CC47421F

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