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Issue 40, 2014
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γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation

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Abstract

We report the design, synthesis, characterization and evaluation of a novel class of γ-AApeptide one-bead-one-compound (OBOC) library, from which a small γ-AApeptide was identified to effectively prevent and disassemble Aβ aggregation.

Graphical abstract: γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation

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Article information


Submitted
01 Sep 2013
Accepted
10 Oct 2013
First published
10 Oct 2013

Chem. Commun., 2014,50, 5206-5208
Article type
Communication

γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation

H. Wu, Y. Li, G. Bai, Y. Niu, Q. Qiao, J. D. Tipton, C. Cao and J. Cai, Chem. Commun., 2014, 50, 5206
DOI: 10.1039/C3CC46685J

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