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Issue 2, 2014
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Unusual ECD fragmentation attributed to gas-phase helix formation in a conformationally dynamic peptide

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Abstract

The helix-forming character of a model decapeptide, L4PL4K, is determined in the absence of solvent using ion mobility mass spectrometry, electron capture dissociation and molecular mechanics simulations. Unusual ECD fragmentation patterns dominated by b ions are attributed to helix formation upon electron capture and as a signature of conformational dynamics.

Graphical abstract: Unusual ECD fragmentation attributed to gas-phase helix formation in a conformationally dynamic peptide

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Publication details

The article was received on 19 Aug 2013, accepted on 15 Oct 2013 and first published on 16 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC46356G
Citation: Chem. Commun., 2014,50, 198-200
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    Unusual ECD fragmentation attributed to gas-phase helix formation in a conformationally dynamic peptide

    J. M. D. Kalapothakis, Y. Berezovskaya, C. G. Zampronio, P. A. Faull, P. E. Barran and H. J. Cooper, Chem. Commun., 2014, 50, 198
    DOI: 10.1039/C3CC46356G

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