Nitrite is an important reservoir of nitric oxide activity in the plasma and cells. Using a biomimetic model, we demonstrate the conversion of zinc-bound nitrite in the tris(pyrazolyl)borate complex iPr2TpZn(NO2) to the corresponding S-nitrosothiol RSNO and zinc thiolate iPr2TpZn–SR via reaction with thiols H–SR. Decomposition of the S-nitrosothiol formed releases nitric oxide gas.
A. J. P. Cardenas, R. Abelman and T. H. Warren, Chem. Commun., 2014, 50, 168 DOI: 10.1039/C3CC46102E
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