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Issue 6, 2014
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Digital drug delivery: on–off ultrasound controlled antibiotic release from coated matrices with negligible background leaching

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Abstract

Hydrogels such as crosslinked poly(2-hydroxyethyl methacrylate) (pHEMA) have been used extensively in controlled release drug delivery systems. Our previous work demonstrated an ultrasound (US)-responsive system based on pHEMA coated with a self-assembled multilayer of C12–C18 methylene chains. The resulting coating was predominantly crystalline and relatively impermeable, forming an US-activated switch that controlled drug release on-demand, and kept the drug within the matrix in the absence of US. The device, as developed did, however, show a low background drug-leaching rate independent of US irradiation. For some applications, it is desirable to have very low or zero background release rates. This was achieved here by a combination of new processing steps, and by co-polymerizing HEMA with a relatively hydrophobic monomer, hydroxypropyl methacrylate (HPMA). These advances produced systems with undetectable ciprofloxacin background release rates that are capable of US-facilitated drug release – up to 14-fold increases relative to controls both before and after US exposure. In addition, these observations are consistent with the hypothesis that US-mediated disorganization of the coating allows a transient flux of water into the matrix where its interaction with bound and dissolved drug facilitates its movement both within and out of the matrix.

Graphical abstract: Digital drug delivery: on–off ultrasound controlled antibiotic release from coated matrices with negligible background leaching

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Publication details

The article was received on 27 Aug 2013, accepted on 21 Jan 2014 and first published on 12 Feb 2014


Article type: Paper
DOI: 10.1039/C3BM60203F
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Biomater. Sci., 2014,2, 893-902

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    Digital drug delivery: on–off ultrasound controlled antibiotic release from coated matrices with negligible background leaching

    M. L. Noble, P. D. Mourad and B. D. Ratner, Biomater. Sci., 2014, 2, 893
    DOI: 10.1039/C3BM60203F

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