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Issue 1, 2014
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Honeycomb-shaped surface topography induces differentiation of human mesenchymal stem cells (hMSCs): uniform porous polymer scaffolds prepared by the breath figure technique

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Abstract

Polystyrene honeycomb scaffolds with different pore sizes were successfully fabricated by casting a polymer solution under humid conditions in order to investigate the effect of porous microtopography on hMSC differentiation. We have used honeycomb scaffolds to achieve the microtopography-induced differentiation of hMSCs. Honeycomb scaffolds led hMSCs to osteospecific and myospecific differentiations depending on the size of pores. This selective differentiation suggested that surface microtopography alone may be effective for using hMSCs in regenerative medicine and tissue engineering.

Graphical abstract: Honeycomb-shaped surface topography induces differentiation of human mesenchymal stem cells (hMSCs): uniform porous polymer scaffolds prepared by the breath figure technique

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Supplementary files

Article information


Submitted
19 Aug 2013
Accepted
25 Sep 2013
First published
14 Oct 2013

Biomater. Sci., 2014,2, 52-56
Article type
Paper

Honeycomb-shaped surface topography induces differentiation of human mesenchymal stem cells (hMSCs): uniform porous polymer scaffolds prepared by the breath figure technique

T. Kawano, M. Sato, H. Yabu and M. Shimomura, Biomater. Sci., 2014, 2, 52
DOI: 10.1039/C3BM60195A

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