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Issue 10, 2014
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Molecular modelling and synthesis of a polymer for the extraction of amiloride and triamterene from human urine

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Abstract

A new solid-phase extraction resin with high affinity towards amiloride and triamterene was developed with the assistance of computational modelling. Itaconic acid was selected as the best functional monomer capable of forming strong complexes with amiloride and triamterene. Conditions for selective solid-phase extraction of the diuretics from human urine and for their separation using a custom-designed adsorbent were optimised. It was shown that this adsorbent provided a high level of purification of the diuretics from human urine, which made their quantification using spectrophotometry possible.

Graphical abstract: Molecular modelling and synthesis of a polymer for the extraction of amiloride and triamterene from human urine

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Publication details

The article was received on 07 Feb 2014, accepted on 25 Mar 2014 and first published on 26 Mar 2014


Article type: Paper
DOI: 10.1039/C4AY00318G
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Anal. Methods, 2014,6, 3429-3435

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    Molecular modelling and synthesis of a polymer for the extraction of amiloride and triamterene from human urine

    I. Tsyrulneva, O. Zaporozhets, E. Piletska and S. Piletsky, Anal. Methods, 2014, 6, 3429
    DOI: 10.1039/C4AY00318G

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