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Issue 20, 2014
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Fluorescent sensors for the basic metabolic panel enable measurement with a smart phone device over the physiological range

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Abstract

The advanced functionality of portable devices such as smart phones provides the necessary hardware to potentially perform complex diagnostic measurements in any setting. Recent research and development have utilized cameras and data acquisition properties of smart phones to create diagnostic approaches for a variety of diseases or pollutants. However, in concentration measurements, such as blood glucose, the performance of handheld diagnostic devices depends largely on the sensing mechanism. To expand measurements to multiple components, often necessary in medical tests, with a single diagnostic device, robust platform based sensors are needed. Here, we developed a suite of dual wavelength fluorescent sensors with response characteristics necessary to measure each component of a basic metabolic panel, a common clinical measurement. Furthermore, the response of these sensors could be measured with a simple optical setup to convert a smart phone into a fluorescence measurement instrument. This approach could be used as a mobile basic metabolic panel measurement system for point of care diagnostics.

Graphical abstract: Fluorescent sensors for the basic metabolic panel enable measurement with a smart phone device over the physiological range

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Article information


Submitted
02 Jun 2014
Accepted
28 Jul 2014
First published
15 Aug 2014

Analyst, 2014,139, 5230-5238
Article type
Paper

Fluorescent sensors for the basic metabolic panel enable measurement with a smart phone device over the physiological range

B. Awqatty, S. Samaddar, K. J. Cash, H. A. Clark and J. M. Dubach, Analyst, 2014, 139, 5230
DOI: 10.1039/C4AN00999A

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