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Issue 15, 2014

Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein

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Abstract

Hypermethylation of CpG islands in gene promoter regions has been shown to be a predictive biomarker for certain diseases. Most current methods for methylation profiling are not well-suited for clinical analysis. Here, we report the development of an inexpensive device and an epigenotyping assay with a format conducive to multiplexed analysis.

Graphical abstract: Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein

Supplementary files

Article information


Submitted
14 Apr 2014
Accepted
28 Apr 2014
First published
28 Apr 2014

This article is Open Access

Analyst, 2014,139, 3695-3701
Article type
Communication

Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein

B. W. Heimer, T. A. Shatova, J. K. Lee, K. Kaastrup and H. D. Sikes, Analyst, 2014, 139, 3695 DOI: 10.1039/C4AN00667D

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