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Issue 13, 2014
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Reversible and selective luminescent determination of ClO/H2S redox cycle in vitro and in vivo based on a ruthenium trisbipyridyl probe

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Abstract

A rapid and highly selective luminescent probe has been developed to determine the in vitro and in vivo ClO/H2S redox cycle using a ruthenium tris-bipyridyl complex covalently linked with phenothiazine. The luminescence intensity was considerably enhanced upon the addition of ClO due to the oxidation of the probe to its sulfoxide derivative, which quickly returned to the original level by the reaction with H2S due to the reconstitution of the probe. The redox cycle can be repeated at least 12 times. Under optimal conditions, the luminescence intensities are linear over the concentration range of 1 × 10−9 to 1 × 10−4 mol L−1 for ClO and 1 × 10−9 to 1 × 10−4 mol L−1 for H2S, and the detection limits are 1.8 × 10−11 mol L−1 for ClO and 1.2 × 10−11 mol L−1 for H2S, which are much lower than those obtained with other detection methods. The proposed method is simple in design and fast in operation, and is suitable for the reversible determination of ClO and H2S in vitro and in vivo with high selectivity.

Graphical abstract: Reversible and selective luminescent determination of ClO−/H2S redox cycle in vitro and in vivo based on a ruthenium trisbipyridyl probe

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Publication details

The article was received on 16 Feb 2014, accepted on 11 Apr 2014 and first published on 11 Apr 2014


Article type: Paper
DOI: 10.1039/C4AN00331D
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Analyst, 2014,139, 3324-3329

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    Reversible and selective luminescent determination of ClO/H2S redox cycle in vitro and in vivo based on a ruthenium trisbipyridyl probe

    F. Liu, Y. Gao, J. Wang and S. Sun, Analyst, 2014, 139, 3324
    DOI: 10.1039/C4AN00331D

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